STIM2 Positive Control for STJ503143 peptide (STJ505176)
SPECIFICATIONS
General Information
| Short Description | STIM2 Positive Control for STJ503143 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications | WB |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | WB: 1:500 |
| Formulation | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | STIM2 |
| Gene ID | 57620 |
| Uniprot ID | STIM2_HUMAN |
| Specificity | This is positive control is recommended for use in combination with STIM2 antibody STJ503143. |
Additional Info
| Tissue Specificity | Expressed in all tissues and tumor cell lines examined. |
| Post Translational Modifications | Glycosylated. Phosphorylated predominantly on Ser residues. |
| Function | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. |
| Peptide Name | Stromal Interaction Molecule 2 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane ProteinDynamically Translocates From A Uniform Endoplasmic Reticulum Distribution To Punctual Endoplasmic Reticulum-Plasma Membrane Junctions In Response To Decrease In Endoplasmic Reticulum Ca(2+) Concentration |
| Alternative Peptide Names | Stromal Interaction Molecule 2 proteinSTIM2 proteinKIAA1482 protein |
Information sourced from Uniprot.org