Sodium/Hydrogen Exchanger 3 Blocking Peptide peptide (STJ504941)
SPECIFICATIONS
ImmunogenSynthetic peptide taken within amino acid region 790-835 on Slc9A3 protein.
General Information
| Short Description | Sodium/Hydrogen Exchanger 3 Blocking Peptide is synthetically produced from the 790-835 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC9A3 |
| Gene ID | 6550 |
| Uniprot ID | SL9A3_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 790-835 on Slc9A3 protein. |
| Immunogen Region | 790-835 |
Additional Info
| Post Translational Modifications | Phosphorylated by PKA, which inhibits activity. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane. Phosphorylation at Ser-718 by CSNK2A1 regulates SLC9A3 activity through the formation of multiple signaling complexes. |
| Function | Plasma membrane Na(+)/H(+) antiporter. Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis. Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation. |
| Peptide Name | Sodium/Hydrogen Exchanger 3Na(+/H(+ Exchanger 3Nhe-3Solute Carrier Family 9 Member 3 |
| Database Links | Reactome: R-HSA-425986 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell MembraneRecycling Endosome MembraneEarly Endosome MembraneIn Intestinal Epithelial CellsLocalizes To The Ileal Brush BorderPhosphorylation At Ser-663 By Sgk1 Is Associated With Increased Abundance At The Cell MembraneAngiotensin-2 Enhances Apical Expression |
| Alternative Peptide Names | Sodium/Hydrogen Exchanger 3 proteinNa(+/H(+ Exchanger 3 proteinNhe-3 proteinSolute Carrier Family 9 Member 3 proteinSLC9A3 proteinNHE3 protein |
Information sourced from Uniprot.org