Slingshot homolog 1 Blocking Peptide for STJ502682 is synthetically produced from the sequence and is suitable for use in western blot applications.
Applications
Immunodepletion/Immunocompetition
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Formulation
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction
Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Synthetic peptide corresponding to unique amino acid sequence on Slingshot homolog 1 protein.
Specificity
This blocking peptide is recommended for use in combination with Slingshot homolog 1 antibody, STJ502682
Additional Info
Post Translational Modifications
Phosphorylated. Inhibitory phosphorylation by PAK4 promotes binding to YWHAZ. Phosphorylation at Ser-978 is decreased by stimuli which promote actin reorganization and lamellipodia formation. Can be dephosphorylated and activated by PPP3CA/calcineurin A. Phosphorylation decreases immediately prior to telophase.
Function
Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.
Peptide Name
Protein Phosphatase Slingshot Homolog 1Ssh-Like Protein 1Ssh-1lHssh-1l
Cellular Localisation
CytoplasmCytoskeletonCell ProjectionLamellipodiumCleavage FurrowMidbodyAlso Recruited To Actin Rich Membrane Protrusions Such As LamellipodiaWhich May Allow Local Control Of Actin Dynamics At Sites Of Cell LocomotionAlso Localized To The Cleavage Furrow And The Midbody During Cytokinesis
Alternative Peptide Names
Protein Phosphatase Slingshot Homolog 1 proteinSsh-Like Protein 1 proteinSsh-1l proteinHssh-1l proteinSSH1 proteinKIAA1298 proteinSSH1L protein
