SLC7A10 Blocking Peptide for STJ500168 is synthetically produced from the 450-500 sequence and is suitable for use in western blot applications.
Applications
Immunodepletion/Immunocompetition
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Formulation
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction
Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Synthetic peptide taken within amino acid region 450-500 on rat Asc-type amino acid transporter 1 protein.
Immunogen Region
450-500
Specificity
This blocking peptide is recommended for use in combination with SLC7A10 antibody, STJ500168
Additional Info
Tissue Specificity
Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.
Function
Associates with SLC3A2/4F2hc to form a functional heterodimeric complex that translocates small neutral L- and D-amino acids across the plasma membrane. Preferentially mediates exchange transport, but can also operate via facilitated diffusion. Acts as a major transporter for glycine, L- and D-serine in the central nervous system. At the spinal cord and brainstem regulates glycine metabolism and glycinergic inhibitory neurotransmission by providing for glycine de novo synthesis from L-serine and glycine recycling from astrocytes to glycinergic motor neurons. At Schaffer collateral-CA1 synapses mediates D-serine and glycine release that modulates post-synaptic activation of NMDA receptors and excitatory glutamatergic transmission. May regulate D-serine release from mesenchymal progenitors located in developing subcutaneous adipose tissue, favoring white adipocyte over thermogenic beige adipocyte lineage commitment.
Peptide Name
Asc-Type Amino Acid Transporter 1Asc-1Solute Carrier Family 7 Member 10
Cell MembraneMulti-Pass Membrane ProteinColocalizes With Olig2 In Astrocytic ProcessesLocalizes To The Plasma Membrane In Mature Adipocytes And To Intracellular Structures In Preadipocytes
Alternative Peptide Names
Asc-Type Amino Acid Transporter 1 proteinAsc-1 proteinSolute Carrier Family 7 Member 10 proteinSLC7A10 proteinASC1 protein
