SLC29A3 Blocking Peptide for STJ500885 is synthetically produced from the 1-60 sequence and is suitable for use in western blot applications.
Applications
Immunodepletion/Immunocompetition
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Formulation
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction
Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Synthetic peptide taken within amino acid region 1-60 on ENT3 protein.
Immunogen Region
1-60
Specificity
This blocking peptide is recommended for use in combination with SLC29A3 antibody, STJ500885
Additional Info
Tissue Specificity
Widely expressed in both adult and fetal tissues. Highest levels in placenta, uterus, ovary, spleen, lymph node and bone marrow. Expressed in liver. Lowest levels in brain and heart. Expressed in macrophages.
Function
Uniporter that mediates the facilitative transport of nucleoside across lysosomal and mitochondrial membranes. Functions as a non-electrogenic Na(+)-independent transporter. Substrate transport is pH-dependent and enhanced under acidic condition, probably reflecting the location of the transporter in acidic intracellular compartments. Proton is not a cotransporting ion but most likely change the ionization state of the transporter which dictates transport-permissible/impermissible conformation for nucleoside translocation. May direct the nucleoside transport from lysosomes to cytosol or cytosol to mitochondria to facilitate the fundamental function of salvage synthesis of nucleic acids. Involved in the transport of nucleosides (adenosine, guanosine, uridine, thymidine, cytidine and inosine) and deoxynucleosides (deoxyadenosine, deoxycytidine). Also mediates transport of purine nucleobases (adenine, guanine) and pyrimidine nucleobases (uracil). Also able to transport monoamine neurotransmitters dopamine, serotonin, noradrenaline and tyramine. Capable of transporting ATP. Mediates nucleoside export from lysosomes in macrophages, which regulates macrophage functions and numbers.
Peptide Name
Equilibrative Nucleoside Transporter 3Hent3Solute Carrier Family 29 Member 3
Lysosome MembraneMulti-Pass Membrane ProteinLate Endosome MembraneMitochondrion MembraneCell MembraneObserved In A Punctate Intracellular Pattern Showing Partial Colocalization With Late Endosomes/LysosomesDetected At The Cell Surface Only In Certain Placental Cells
Alternative Peptide Names
Equilibrative Nucleoside Transporter 3 proteinHent3 proteinSolute Carrier Family 29 Member 3 proteinSLC29A3 proteinENT3 proteinUNQ717 proteinPRO1380 protein
