SGK2 Positive Control for STJ502983 peptide (STJ505141)

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STJ505141-5
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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : SGK2 Positive Control for STJ502983 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: SGK2
Gene ID: 10110
Uniprot ID: SGK2_HUMAN
Specificity: This is positive control is recommended for use in combination with SGK2 antibody STJ502983.
Tissue Specificity Highly expressed in liver, kidney and pancreas, and at lower levels in brain.
Post Translational Modifications Activated by phosphorylation on Ser-356 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-193.
Function Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.
Peptide Name Serine/Threonine-Protein Kinase Sgk2
Serum/Glucocorticoid-Regulated Kinase 2
Database Links Reactome: R-HSA-2672351
Cellular Localisation Cytoplasm
Nucleus
Alternative Peptide Names Serine/Threonine-Protein Kinase Sgk2 protein
Serum/Glucocorticoid-Regulated Kinase 2 protein
SGK2 protein

Information sourced from Uniprot.org

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