RNase 7 protein (STJP000162)
SPECIFICATIONS
HostCHO cells
General Information
| Short Description | RNase 7-protein was developed from cho cells. For use in research applications. |
| Host | CHO cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1.9 mg/ml |
| Purification | Purified by affinity chromatography and gel-filtration from serum-free CHO growth media. |
| Formulation | 10 mM acetate, pH 5.0; 150 mM NaCl |
| Storage Instruction | Store at-70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles. |
Target Information
| Gene Symbol | RNASE7 |
| Gene ID | 84659 |
| Uniprot ID | RNAS7_HUMAN |
Additional Info
| Function | Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms including uropathogenic E.coli (UPEC), and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium. Causes loss of bacterial membrane integrity. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity. |
| Protein Name | Ribonuclease 7Rnase 7Skin-Derived Antimicrobial Protein 2Sap-2 |
| Database Links | Reactome: R-HSA-6803157 |
| Cellular Localisation | SecretedDetected In Urine |
| Alternative Protein Names | Ribonuclease 7 proteinRnase 7 proteinSkin-Derived Antimicrobial Protein 2 proteinSap-2 proteinRNASE7 proteinUNQ2516 proteinPRO6006 protein |
Information sourced from Uniprot.org