| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
RIPK5 Blocking Peptide is synthetically produced from the 200-250 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
DSTYK |
| Gene ID: |
25778 |
| Uniprot ID: |
DUSTY_HUMAN |
| Immunogen Region: |
200-250 |
| Immunogen: |
Synthetic peptide taken within amino acid region 200-250 on human Dual serine/threonine and tyrosine protein kinase protein (RIPK5). |
| Tissue Specificity | Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines. Expressed in the skin. |
| Function | Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types. |
| Peptide Name | Dual Serine/Threonine And Tyrosine Protein KinaseDusty Protein KinaseDusty PkRip-Homologous KinaseReceptor-Interacting Serine/Threonine-Protein Kinase 5Sugen Kinase 496Sgk496 |
| Cellular Localisation | CytoplasmCell MembraneApical Cell MembraneBasolateral Cell MembraneCell JunctionDetected At Apical Cell-Cell JunctionsColocalized With Fgf Receptors To The Cell MembraneDetected In Basolateral And Apical Membranes Of All Tubular Epithelia |
| Alternative Peptide Names | Dual Serine/Threonine And Tyrosine Protein Kinase proteinDusty Protein Kinase proteinDusty Pk proteinRip-Homologous Kinase proteinReceptor-Interacting Serine/Threonine-Protein Kinase 5 proteinSugen Kinase 496 proteinSgk496 proteinDSTYK proteinKIAA0472 proteinRIP5 proteinRIPK5 proteinSGK496 proteinHDCMD38P protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
