RIP140 Blocking Peptide peptide (STJ504858)

SKU:
STJ504858-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: RIP140 Blocking Peptide is synthetically produced from the 740-690 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Nrip1
Gene ID: 268903
Uniprot ID: NRIP1_MOUSE
Immunogen Region: 740-690
Immunogen: Synthetic peptide taken within amino acid region 740-690 on mouse receptor interacting protein 140.
Tissue Specificity Expressed in the embryonic placenta. In the adult, expression is strong in the testis and brain. Also expressed at a high level in the white adipose tissue. Expressed constantly but at a weaker level in the adult heart, lung, stomach and kidney. Expressed moderately in the skeletal muscle. Expressed at a low level in the adult spleen, liver and brown adipose tissue. Expressed in the ovary at a high level in granulosa cells and at a lower level in the thecal and interstitial compartments.
Post Translational Modifications Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH. Acetylation regulates its nuclear translocation and corepressive activity.
Function Modulates transcriptional repression by nuclear hormone receptors such as NR2C1, thyroid hormone receptor and retinoic acid receptor/RARA. Essential for cumulus expansion and follicle rupture during ovulation. Also controls the balance between fat accumulation and energy expenditure. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function. Plays a role in renal development.
Peptide Name Nuclear Receptor-Interacting Protein 1
Nuclear Factor Rip140
Receptor-Interacting Protein 140
Database Links Reactome: R-MMU-3899300
Reactome: -MMU-9018519
Cellular Localisation Nucleus
Alternative Peptide Names Nuclear Receptor-Interacting Protein 1 protein
Nuclear Factor Rip140 protein
Receptor-Interacting Protein 140 protein
Nrip1 protein

Information sourced from Uniprot.org

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