| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | RIP140 Blocking Peptide is synthetically produced from the 740-690 sequence and is suitable for use in western blot applications. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | Nrip1 |
| Gene ID: | 268903 |
| Uniprot ID: | NRIP1_MOUSE |
| Immunogen Region: | 740-690 |
| Immunogen: | Synthetic peptide taken within amino acid region 740-690 on mouse receptor interacting protein 140. |
| Tissue Specificity | Expressed in the embryonic placenta. In the adult, expression is strong in the testis and brain. Also expressed at a high level in the white adipose tissue. Expressed constantly but at a weaker level in the adult heart, lung, stomach and kidney. Expressed moderately in the skeletal muscle. Expressed at a low level in the adult spleen, liver and brown adipose tissue. Expressed in the ovary at a high level in granulosa cells and at a lower level in the thecal and interstitial compartments. |
| Post Translational Modifications | Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH. Acetylation regulates its nuclear translocation and corepressive activity. |
| Function | Modulates transcriptional repression by nuclear hormone receptors such as NR2C1, thyroid hormone receptor and retinoic acid receptor/RARA. Essential for cumulus expansion and follicle rupture during ovulation. Also controls the balance between fat accumulation and energy expenditure. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function. Plays a role in renal development. |
| Peptide Name | Nuclear Receptor-Interacting Protein 1 Nuclear Factor Rip140 Receptor-Interacting Protein 140 |
| Database Links | Reactome: R-MMU-3899300 Reactome: -MMU-9018519 |
| Cellular Localisation | Nucleus |
| Alternative Peptide Names | Nuclear Receptor-Interacting Protein 1 protein Nuclear Factor Rip140 protein Receptor-Interacting Protein 140 protein Nrip1 protein |
Information sourced from Uniprot.org