| Applications: |
ELISA |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.138ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This PPM1A Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat tissue homogenates, cell lysates or other biological fluids.. |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Ppm1a |
| Gene ID: |
24666 |
| Uniprot ID: |
PPM1A_RAT |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | N-myristoylation is essential for the recognition of its substrates for dephosphorylation. |
| Function | Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. |
| Protein Name | Protein Phosphatase 1aProtein Phosphatase 2c Isoform AlphaPp2c-AlphaProtein Phosphatase Ia |
| Database Links | Reactome: R-RNO-2173795Reactome: -RNO-380972 |
| Cellular Localisation | NucleusCytoplasmCytosolMembraneLipid-AnchorWeakly Associates At The Membrane And N-Myristoylation Mediates The Membrane Localization |
| Alternative ELISA Names | Protein Phosphatase 1a ELISA kitProtein Phosphatase 2c Isoform Alpha ELISA kitPp2c-Alpha ELISA kitProtein Phosphatase Ia ELISA kitPpm1a ELISA kitPp2c1 ELISA kitPppm1a ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
