Rat MMP3 (MMP3) Antibody Pair (STJAP00791)
General Information
| Short Description | This MMP3 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Clone ID | R67-5G-2/R34-4F-3 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | Determined by end user |
| Formulation | 0.01M PBS, pH 7.2 |
| Storage Instruction | Store at 4Β°C short term. Aliquot and store at-20Β°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | Mmp3Uniprot ID=MMP3_RAT" |
| Immunogen | Recombinant protein |
Additional Info
| Function | Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V.collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V.collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9. Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway. Also acts intracellularly. For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage. In addition, plays a role in immune response and possesses antiviral activity against various viruses. Mechanistically, translocates from the cytoplasm into the cell nucleus upon virus infection to influence NF-kappa-B activities. |
| Protein Name | Stromelysin-1Sl-1Matrix Metalloproteinase-3Mmp-3Ptr1 ProteinTransin-1 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Pair Names | Stromelysin-1 antibody pairSl-1 antibody pairMatrix Metalloproteinase-3 antibody pairMmp-3 antibody pairPtr1 Protein antibody pairTransin-1 antibody pairMmp3 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Rat MMP3 (MMP3) Antibody Pair (STJAP00791)
This antibody pair is designed to detect rat MMP3 (Matrix Metalloproteinase 3), corresponding to UniProt entry P03957. Reactivity has been confirmed for rat samples only.
This antibody pair has been validated for use in ELISA. It is intended for sandwich ELISA development, with one antibody serving as the capture and the other as the detection component.
Both antibodies are rabbit monoclonal IgGs (clone IDs R67-5G-2 and R34-4F-3), supplied unconjugated at 1 mg/mL in 0.01M PBS, pH 7.2, and purified by affinity chromatography. The antibodies are supplied unconjugated, so the user is responsible for labeling the detection antibody as required for their assay format.
Optimal working concentrations for both the capture and detection antibodies should be determined by the end user through titration experiments, as predefined dilution ranges are not specified for this product.
Both antibodies should be stored at 4Β°C for short-term use. For long-term storage, aliquot and store at -20Β°C. Repeated freeze/thaw cycles should be avoided to maintain antibody integrity.
Both antibodies were raised in rabbit against a recombinant rat MMP3 protein. No additional specificity or cross-reactivity data are provided in the current product details, so users should perform appropriate controls when testing samples that may contain related MMP family members.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.