Rat CCL2/MCP-1 protein (Recombinant) (C-His) (STJP001152)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Rat CCL2/MCP-1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln24-Asn148) of rat CCL2/JE/MCP-1 (Accession #NP_113718.1.) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Rat CCL2/MCP-1-C-His protein was developed in hek293 cells using the region Gln24-Asn148. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | Ccl2 |
| Gene ID | 24770 |
| Uniprot ID | CCL2_RAT |
| Immunogen | Recombinant Rat CCL2/MCP-1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln24-Asn148) of rat CCL2/JE/MCP-1 (Accession #NP_113718.1.) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Gln24-Asn148 |
| Immunogen Sequence | QPDAVNAPLTCCYSFTGKMI PMSRLENYKRITSSRCPKEA VVFVTKLKREICADPNKEWV QKYIRKLDQNQVRSETTVFY KIASTLRTSAPLNVNLTHKS EANASTLFSTTTSSTSVEVT SMTEN |
Additional Info
| Function | Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. |
| Protein Name | C-C Motif Chemokine 2Immediate-Early Serum-Responsive Protein JeMonocyte Chemoattractant Protein 1Monocyte Chemotactic Protein 1Mcp-1Small-Inducible Cytokine A2 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 2 proteinImmediate-Early Serum-Responsive Protein Je proteinMonocyte Chemoattractant Protein 1 proteinMonocyte Chemotactic Protein 1 proteinMcp-1 proteinSmall-Inducible Cytokine A2 proteinCcl2 proteinJe proteinMcp1 proteinScya2 protein |
Information sourced from Uniprot.org