This rat BMP-4 kit is a highly sensitive in-vitro chemiluminescent immunoassay for the measurement of trace amounts of analytes in serum, plasma and other biological fluids.
Applications
CLIA
Reactivity
Rat
Sensitivity
4.69pg/mL
Detection Limit
7.81~500pg/mL
Note
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Product Properties
Storage Instruction
If unopened the kit may be stored at 2-8°C for up to 1 month. If the kit will not be used within 1 month, store the components separately, according to the component table in the manual.
This kit recognizes Rat BMP-4 in samples. No significant cross-reactivity or interference between Rat BMP-4 and analogues was observed.
Sample Type
Serum, plasma and other biological fluids
Additional Info
Function
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Positively regulates the expression of odontogenic development regulator MSX1 via inducing the IPO7-mediated import of SMAD1 to the nucleus. Required for MSX1-mediated mesenchymal molar tooth bud development beyond the bud stage, via promoting Wnt signaling. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling. Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway. Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt, or SRC cascades. For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response.
Protein Name
Bone Morphogenetic Protein 4Bmp-4Bone Morphogenetic Protein 2bBmp-2b
Cellular Localisation
SecretedExtracellular SpaceExtracellular Matrix
Alternative CLIA Names
Bone Morphogenetic Protein 4 CLIA kitBmp-4 CLIA kitBone Morphogenetic Protein 2b CLIA kitBmp-2b CLIA kitBmp4 CLIA kitBmp-4 CLIA kitDvr-4 CLIA kit
Specificity
This kit recognizes Rat BMP-4 in samples. No significant cross-reactivity or interference between Rat BMP-4 and analogues was observed.
