| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
PREX2 Positive Control for STJ502653 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500-1:750 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
PREX2 |
| Gene ID: |
80243 |
| Uniprot ID: |
PREX2_HUMAN |
| Specificity: |
This is positive control is recommended for use in combination with PREX2 antibody STJ502653. |
| Tissue Specificity | Isoform 1 is highly expressed in skeletal muscle, heart and placenta, absent from peripheral blood leukocytes. Isoform 2 is expressed in skeletal muscle, kidney, small intestine, and placenta. Isoform 3 is expressed in the heart. |
| Function | Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase. |
| Peptide Name | Phosphatidylinositol 3 -4 -5-Trisphosphate-Dependent Rac Exchanger 2 ProteinP-Rex2Ptdins(3 -4 -5-Dependent Rac Exchanger 2Dep Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-8948751Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Alternative Peptide Names | Phosphatidylinositol 3 -4 -5-Trisphosphate-Dependent Rac Exchanger 2 Protein proteinP-Rex2 proteinPtdins(3 -4 -5-Dependent Rac Exchanger 2 proteinDep Domain-Containing Protein 2 proteinPREX2 proteinDEPDC2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
