PREX1 Blocking Peptide for STJ502650 peptide (STJ504797)
SPECIFICATIONS
ImmunogenSynthetic peptide corresponding to aino acid region 815-836 of Human PREX1. Peptide was covalently modified. Sequence: QEEDQADSAFPLLSLGPRLSLC
General Information
| Short Description | PREX1 Blocking Peptide for STJ502650 is synthetically produced from the 815-836 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | PREX1 |
| Gene ID | 57580 |
| Uniprot ID | PREX1_HUMAN |
| Immunogen | Synthetic peptide corresponding to aino acid region 815-836 of Human PREX1. Peptide was covalently modified. Sequence: QEEDQADSAFPLLSLGPRLSLC |
| Immunogen Region | 815-836 |
| Specificity | This blocking peptide is recommended for use in combination with PREX1 antibody, STJ502650 |
Additional Info
| Tissue Specificity | Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues. |
| Function | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
| Peptide Name | Phosphatidylinositol 3 -4 -5-Trisphosphate-Dependent Rac Exchanger 1 ProteinP-Rex1Ptdins(3 -4 -5-Dependent Rac Exchanger 1 |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013406Reactome: R-HSA-9013408Reactome: R-HSA-9013409Reactome: R-HSA-9013423 |
| Cellular Localisation | CytoplasmCytosolCell MembraneMainly CytosolicSome Amount Is Apparently Associated To The Plasma Membrane |
| Alternative Peptide Names | Phosphatidylinositol 3 -4 -5-Trisphosphate-Dependent Rac Exchanger 1 Protein proteinP-Rex1 proteinPtdins(3 -4 -5-Dependent Rac Exchanger 1 proteinPREX1 proteinKIAA1415 protein |
Information sourced from Uniprot.org