Presenilin 1 Positive Control peptide (STJ504812)

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STJ504812-5

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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Presenilin 1 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PSEN1
Gene ID: 5663
Uniprot ID: PSN1_HUMAN
Tissue Specificity Detected in azurophile granules in neutrophils and in platelet cytoplasmic granules (at protein level). Expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes.
Post Translational Modifications Heterogeneous proteolytic processing generates N-terminal (NTF) and C-terminal (CTF) fragments of approximately 35 and 20 kDa, respectively. During apoptosis, the C-terminal fragment (CTF) is further cleaved by caspase-3 to produce the fragment, PS1-CTF12. After endoproteolysis, the C-terminal fragment (CTF) is phosphorylated on serine residues by PKA and/or PKC. Phosphorylation on Ser-346 inhibits endoproteolysis.
Function Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1.this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin). Under conditions of apoptosis or calcium influx, cleaves CDH1. This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling. Required for normal embryonic brain and skeleton development, and for normal angiogenesis. Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis. Involved in the regulation of neurite outgrowth. Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression.
Peptide Name Presenilin-1
Ps-1
Protein S182 Cleaved Into - Presenilin-1 Ntf Subunit - Presenilin-1 Ctf Subunit - Presenilin-1 Ctf12
Ps1-Ctf12
Database Links Reactome: R-HSA-1251985
Reactome: R-HSA-1474228
Reactome: R-HSA-193692
Reactome: R-HSA-205043
Reactome: R-HSA-2122948
Reactome: R-HSA-2644606
Reactome: R-HSA-2894862
Reactome: R-HSA-2979096
Reactome: R-HSA-3928665
Reactome: R-HSA-6798695
Reactome: R-HSA-9013507
Reactome: R-HSA-9013700
Reactome: R-HSA-9017802
Cellular Localisation Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Golgi Apparatus Membrane
Cytoplasmic Granule
Cell Membrane
Cell Projection
Growth Cone
Early Endosome
Early Endosome Membrane
Neuron Projection
Axon
Synapse
Translocates With Bound Notch1 From The Endoplasmic Reticulum And/Or Golgi To The Cell Surface
Colocalizes With Cdh1/2 At Sites Of Cell-Cell Contact
Colocalizes With Ctnnb1 In The Endoplasmic Reticulum And The Proximity Of The Plasma Membrane
Also Present In Azurophil Granules Of Neutrophils
Colocalizes With Ubqln1 In The Cell Membrane And In Cytoplasmic Juxtanuclear Structures Called Aggresomes
Alternative Peptide Names Presenilin-1 protein
Ps-1 protein
Protein S182 Cleaved Into - Presenilin-1 Ntf Subunit - Presenilin-1 Ctf Subunit - Presenilin-1 Ctf12 protein
Ps1-Ctf12 protein
PSEN1 protein
AD3 protein
PS1 protein
PSNL1 protein

Information sourced from Uniprot.org

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