| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | PP2A-gamma Positive Control for STJ505958 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | PPP2R5C |
| Gene ID: | 5527 |
| Uniprot ID: | 2A5G_HUMAN |
| Specificity: | This is positive control is recommended for use in combination with PP2A-gamma antibody STJ505958. |
| Immunogen: | Purified Serine/Threonine-Protein Phosphatase 2A B56 Gamma1 subunit. |
| Post Translational Modifications | Isoform Gamma-3 is phosphorylated on serine residues. Isoform Gamma-1 phosphorylation by ERK2 is IER3-dependent and inhibits ERK dephosphorylation by PP2A-PPP2R5C. |
| Function | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. |
| Peptide Name | Serine/Threonine-Protein Phosphatase 2a 56 Kda Regulatory Subunit Gamma IsoformPp2a B Subunit Isoform B'-GammaPp2a B Subunit Isoform B56-GammaPp2a B Subunit Isoform Pr61-GammaPp2a B Subunit Isoform R5-GammaRenal Carcinoma Antigen Ny-Ren-29 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-195253Reactome: R-HSA-196299Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-389513Reactome: R-HSA-432142Reactome: R-HSA-4641262Reactome: R-HSA-5339716Reactome: R-HSA-5358747Reactome: R-HSA-5358749Reactome: R-HSA-5358751Reactome: R-HSA-5358752Reactome: R-HSA-5467337Reactome: R-HSA-5467340Reactome: R-HSA-5467348Reactome: R-HSA-5663220Reactome: R-HSA-5673000Reactome: R-HSA-5675221Reactome: R-HSA-6804757Reactome: R-HSA-6811558Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusChromosomeCentromere |
| Alternative Peptide Names | Serine/Threonine-Protein Phosphatase 2a 56 Kda Regulatory Subunit Gamma Isoform proteinPp2a B Subunit Isoform B'-Gamma proteinPp2a B Subunit Isoform B56-Gamma proteinPp2a B Subunit Isoform Pr61-Gamma proteinPp2a B Subunit Isoform R5-Gamma proteinRenal Carcinoma Antigen Ny-Ren-29 proteinPPP2R5C proteinKIAA0044 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance