| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | PP2A-beta Positive Control for STJ505948 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | PPP2R5B |
| Gene ID: | 5526 |
| Uniprot ID: | 2A5B_HUMAN |
| Specificity: | This is positive control is recommended for use in combination with PP2A-beta antibody STJ505948. |
| Immunogen: | Purified Serine/Threonine-Protein Phosphatase 2A 56 kDa regulatory Beta subunit. |
| Post Translational Modifications | Ubiquitinated by E3 CUL3-KLHL15 complex.this modification leads to proteasomal degradation. |
| Function | As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. |
| Peptide Name | Serine/Threonine-Protein Phosphatase 2a 56 Kda Regulatory Subunit Beta IsoformPp2a B Subunit Isoform B'-BetaPp2a B Subunit Isoform B56-BetaPp2a B Subunit Isoform Pr61-BetaPp2a B Subunit Isoform R5-Beta |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-195253Reactome: R-HSA-196299Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-381038Reactome: R-HSA-389513Reactome: R-HSA-432142Reactome: R-HSA-4641262Reactome: R-HSA-5339716Reactome: R-HSA-5358747Reactome: R-HSA-5358749Reactome: R-HSA-5358751Reactome: R-HSA-5358752Reactome: R-HSA-5467337Reactome: R-HSA-5467340Reactome: R-HSA-5467348Reactome: R-HSA-5663220Reactome: R-HSA-5673000Reactome: R-HSA-5675221Reactome: R-HSA-6811558Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | Cytoplasm |
| Alternative Peptide Names | Serine/Threonine-Protein Phosphatase 2a 56 Kda Regulatory Subunit Beta Isoform proteinPp2a B Subunit Isoform B'-Beta proteinPp2a B Subunit Isoform B56-Beta proteinPp2a B Subunit Isoform Pr61-Beta proteinPp2a B Subunit Isoform R5-Beta proteinPPP2R5B protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance