| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
PNPLA3 Blocking Peptide for STJ502570 is synthetically produced from the 150-200 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
PNPLA3 |
| Gene ID: |
80339 |
| Uniprot ID: |
PLPL3_HUMAN |
| Immunogen Region: |
150-200 |
| Specificity: |
This blocking peptide is recommended for use in combination with PNPLA3 antibody, STJ502570 |
| Immunogen: |
Synthetic peptide taken within amino acid region 150-200 on human Patatin-like phospholipase domain-containing protein 3. |
| Function | Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA. Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides. In vitro may express hydrolytic activity against glycerolipids triacylglycerol, diacylglycerol and monoacylglycerol, with a strong preference for oleic acid as the acyl moiety. However, the triacylglycerol hydrolase activity is controversial and may be very low. Possesses phospholipase A2 activity. |
| Peptide Name | 1-Acylglycerol-3-Phosphate O-Acyltransferase Pnpla3Acylglycerol TransacylaseAdiponutrinAdpnCalcium-Independent Phospholipase A2-EpsilonIpla2-EpsilonLysophosphatidic Acid AcyltransferasePatatin-Like Phospholipase Domain-Containing Protein 3 |
| Database Links | Reactome: R-HSA-1482883 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane ProteinLipid Droplet |
| Alternative Peptide Names | 1-Acylglycerol-3-Phosphate O-Acyltransferase Pnpla3 proteinAcylglycerol Transacylase proteinAdiponutrin proteinAdpn proteinCalcium-Independent Phospholipase A2-Epsilon proteinIpla2-Epsilon proteinLysophosphatidic Acid Acyltransferase proteinPatatin-Like Phospholipase Domain-Containing Protein 3 proteinPNPLA3 proteinADPN proteinC22orf20 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
