Phospholipase A2 Positive Control peptide (Phospho) (STJ504743)
SPECIFICATIONS
General Information
| Short Description | Phospho-Phospholipase A2 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications | WB |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | WB: 1:500 |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | PLAA |
| Gene ID | 9373 |
| Uniprot ID | PLAP_HUMAN |
Additional Info
| Function | Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis. |
| Peptide Name | Phospholipase A-2-Activating ProteinPla2pPlap |
| Cellular Localisation | NucleusCytoplasmSynapseRecruited To Damaged Lysosomes Decorated With K48-Linked Ubiquitin Chains |
| Alternative Peptide Names | Phospholipase A-2-Activating Protein proteinPla2p proteinPlap proteinPLAA proteinPLAP protein |
Information sourced from Uniprot.org