| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
PGCD Positive Control for STJ502462 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Gucy2d |
| Gene ID: |
113911 |
| Uniprot ID: |
GUC2D_RAT |
| Specificity: |
This is positive control is recommended for use in combination with PGCD antibody STJ502462. |
| Tissue Specificity | Specifically expressed in a subpopulation of olfactory sensory neurons. Expressed in the cilia of the olfactory epithelium. |
| Function | Functions as an olfactory receptor activated by a urine odorant, uroguanylin. Activated as well by the volatile semiochemicals carbon disulfide (CS2) and carbon dioxide (CO2). Has guanylate cyclase activity upon binding of the ligand. Activation of GUCY2D neurons leads to the cGMP-dependent activation of the CNGA3 channels, membrane depolarization and an increase in action potential frequency. Signaling pathways activated by GUCY2D may trigger social behaviors such as acquisition of food preference. |
| Peptide Name | Guanylate Cyclase 2dGuanylate Cyclase - OlfactoryOne-GcOlfactory Guanylyl Cyclase Gc-DGc-D |
| Cellular Localisation | Cell ProjectionCilium MembraneSingle-Pass Type I Membrane ProteinColocalized With Ncald At The Apical Region Of The CiliaCoexpresses With Pde2 |
| Alternative Peptide Names | Guanylate Cyclase 2d proteinGuanylate Cyclase - Olfactory proteinOne-Gc proteinOlfactory Guanylyl Cyclase Gc-D proteinGc-D proteinGucy2d proteinGucy2e protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
