PDE9A Positive Control for STJ502390 peptide (STJ504679)

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STJ504679-5

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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: PDE9A Positive Control for STJ502390 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: Apply 15-20 µl per lane
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PDE9A
Gene ID: 5152
Uniprot ID: PDE9A_HUMAN
Specificity: This is positive control is recommended for use in combination with PDE9A antibody STJ502390.
Tissue Specificity Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood. Highest levels in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate. In brain, present in the cortex, cerebellum, and subiculum (at protein level). In heart, primarily localizes to myocytes.
Function Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart. Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory.
Peptide Name High Affinity Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase 9a
Database Links Reactome: R-HSA-418457
Cellular Localisation Isoform Pde9a1: Cell Projection
Ruffle Membrane
Cytoplasm
Perinuclear Region
Golgi Apparatus
Endoplasmic Reticulum
Cell Membrane
Sarcolemma
Isoform Pde9a2: Cell Projection
Isoform Pde9a3: Cytoplasm
Isoform Pde9a17: Cytoplasm
Alternative Peptide Names High Affinity Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase 9a protein
PDE9A protein

Information sourced from Uniprot.org

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