PDE5A Blocking Peptide for STJ502354 peptide (STJ504659)
SPECIFICATIONS
ImmunogenRecombinant protein common to all PDE5A variants corresponding to human PDE5A protein.
General Information
| Short Description | PDE5A Blocking Peptide for STJ502354 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20ยฐC for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | PDE5A |
| Gene ID | 8654 |
| Uniprot ID | PDE5A_HUMAN |
| Immunogen | Recombinant protein common to all PDE5A variants corresponding to human PDE5A protein. |
| Specificity | This blocking peptide is recommended for use in combination with PDE5A antibody, STJ502354 |
Additional Info
| Tissue Specificity | Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung. |
| Post Translational Modifications | Phosphorylation is regulated by binding of cGMP to the two allosteric sites. Phosphorylation by PRKG1 leads to its activation. |
| Function | Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP. |
| Peptide Name | Cgmp-Specific 3' -5'-Cyclic PhosphodiesteraseCgmp-Binding Cgmp-Specific PhosphodiesteraseCgb-Pde |
| Database Links | Reactome: R-HSA-418457Reactome: R-HSA-445355Reactome: R-HSA-9013422 |
| Alternative Peptide Names | Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase proteinCgmp-Binding Cgmp-Specific Phosphodiesterase proteinCgb-Pde proteinPDE5A proteinPDE5 protein |
Information sourced from Uniprot.org