PDE4D PKA site Blocking Peptide peptide (Phospho) (STJ504782)
SPECIFICATIONS
ImmunogenPhosphorylated synthetic peptide selective for PDE4D PKA site taken within amino acid region 50-100 on human PDE4D8 protein.
General Information
| Short Description | Phospho-PDE4D PKA site Blocking Peptide is synthetically produced from the 50-100 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | PDE4D |
| Gene ID | 5144 |
| Uniprot ID | PDE4D_HUMAN |
| Immunogen | Phosphorylated synthetic peptide selective for PDE4D PKA site taken within amino acid region 50-100 on human PDE4D8 protein. |
| Immunogen Region | 50-100 |
Additional Info
| Tissue Specificity | Expressed in colonic epithelial cells (at protein level). Widespread.most abundant in skeletal muscle. Isoform 6: Detected in brain. Isoform 8: Detected in brain, placenta, lung and kidney. Isoform 7: Detected in heart and skeletal muscle. |
| Post Translational Modifications | Long isoforms that share a conserved PKA phosphorylation site in the N-terminus are activated by PKA through phosphorylation. Isoform 3 and isoform 7 are activated by phosphorylation (in vitro), but not isoform 6. Isoform N3 and isoform 12 are phosphorylated on Ser-49, Ser-51, Ser-55 and Ser-59. Sumoylation of long isoforms by PIAS4 augments their activation by PKA phosphorylation and represses their inhibition by ERK phosphorylation. |
| Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. |
| Peptide Name | 3' -5'-Cyclic-Amp Phosphodiesterase 4dDpde3Pde43Camp-Specific Phosphodiesterase 4d |
| Database Links | Reactome: R-HSA-180024Reactome: R-HSA-418555 |
| Cellular Localisation | Apical Cell MembraneCytoplasmMembraneCytoskeletonMicrotubule Organizing CenterCentrosomeFound In The Soluble FractionAssociated With MembranesAnd Associated With The Cytoskeleton And The CentrosomeColocalized With Shank2 To The Apical Membrane Of Colonic Crypt Cells |
| Alternative Peptide Names | 3' -5'-Cyclic-Amp Phosphodiesterase 4d proteinDpde3 proteinPde43 proteinCamp-Specific Phosphodiesterase 4d proteinPDE4D proteinDPDE3 protein |
Information sourced from Uniprot.org