PDE4A1 Positive Control for STJ502283 peptide (STJ504619)
SPECIFICATIONS
General Information
| Short Description | PDE4A1 Positive Control for STJ502283 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications | WB |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | WB: 1:500 |
| Formulation | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Pde4a |
| Gene ID | 25638 |
| Uniprot ID | PDE4A_RAT |
| Specificity | This is positive control is recommended for use in combination with PDE4A1 antibody STJ502283. |
Additional Info
| Tissue Specificity | Isoform 2: Isoform 2 is testis specific. |
| Post Translational Modifications | Isoform 1: Phosphorylated by MAPKAPK2 at Ser-147.it counteracts PKA-induced activation of PDE4A and modulates intracellular cAMP levels. Likely involved in cellular desensitization to cAMP signaling. Proteolytically cleaved by CASP3. |
| Function | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. Isoform 1: Efficiently hydrolyzes cAMP. Isoform 2: Efficiently hydrolyzes cAMP. |
| Peptide Name | 3' -5'-Cyclic-Amp Phosphodiesterase 4aDpde2Camp-Specific Phosphodiesterase 4a |
| Database Links | Reactome: R-RNO-180024Reactome: -RNO-418555 |
| Cellular Localisation | Isoform 2: CytoplasmCytosolMembranePeripheral Membrane Protein |
| Alternative Peptide Names | 3' -5'-Cyclic-Amp Phosphodiesterase 4a proteinDpde2 proteinCamp-Specific Phosphodiesterase 4a proteinPde4a protein |
Information sourced from Uniprot.org