PDE4A1 Blocking Peptide for STJ502282 peptide (STJ504618)
SPECIFICATIONS
ImmunogenSynthetic peptide specific for PDE4A1 protein.
General Information
| Short Description | PDE4A1 Blocking Peptide for STJ502282 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Pde4a |
| Gene ID | 25638 |
| Uniprot ID | PDE4A_RAT |
| Immunogen | Synthetic peptide specific for PDE4A1 protein. |
| Specificity | This blocking peptide is recommended for use in combination with PDE4A1 antibody, STJ502282 |
Additional Info
| Tissue Specificity | Isoform 2: Isoform 2 is testis specific. |
| Post Translational Modifications | Isoform 1: Phosphorylated by MAPKAPK2 at Ser-147.it counteracts PKA-induced activation of PDE4A and modulates intracellular cAMP levels. Likely involved in cellular desensitization to cAMP signaling. Proteolytically cleaved by CASP3. |
| Function | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. Isoform 1: Efficiently hydrolyzes cAMP. Isoform 2: Efficiently hydrolyzes cAMP. |
| Peptide Name | 3' -5'-Cyclic-Amp Phosphodiesterase 4aDpde2Camp-Specific Phosphodiesterase 4a |
| Database Links | Reactome: R-RNO-180024Reactome: -RNO-418555 |
| Cellular Localisation | Isoform 2: CytoplasmCytosolMembranePeripheral Membrane Protein |
| Alternative Peptide Names | 3' -5'-Cyclic-Amp Phosphodiesterase 4a proteinDpde2 proteinCamp-Specific Phosphodiesterase 4a proteinPde4a protein |
Information sourced from Uniprot.org