Phosphorylation at Ser-295 mediates insulin-induced activation of PDE3B.
Function
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process. Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling. Controls cardiac contractility by reducing cAMP concentration in cardiocytes.
Peptide Name
Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3bCgipde1Cgip1Cyclic Gmp-Inhibited Phosphodiesterase BCgi-Pde B
Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3b proteinCgipde1 proteinCgip1 proteinCyclic Gmp-Inhibited Phosphodiesterase B proteinCgi-Pde B proteinPDE3B protein
