PDE3B Positive Control for STJ502271 peptide (STJ505765)

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STJ505765-5

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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: PDE3B Positive Control for STJ502271 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PDE3B
Gene ID: 5140
Uniprot ID: PDE3B_HUMAN
Specificity: This is positive control is recommended for use in combination with PDE3B antibody STJ502271.
Immunogen: Purified Protein
Tissue Specificity Abundant in adipose tissues.
Post Translational Modifications Phosphorylation at Ser-295 mediates insulin-induced activation of PDE3B.
Function Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process. Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling. Controls cardiac contractility by reducing cAMP concentration in cardiocytes.
Peptide Name Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3b
Cgipde1
Cgip1
Cyclic Gmp-Inhibited Phosphodiesterase B
Cgi-Pde B
Database Links Reactome: R-HSA-165160
Reactome: R-HSA-418555
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Alternative Peptide Names Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3b protein
Cgipde1 protein
Cgip1 protein
Cyclic Gmp-Inhibited Phosphodiesterase B protein
Cgi-Pde B protein
PDE3B protein

Information sourced from Uniprot.org

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