PDE3B Blocking Peptide peptide (Phospho) (STJ504779)
SPECIFICATIONS
ImmunogenSynthetic peptide taken within amino acid region 260-310 on human PDE3B protein. Selective only for PDE3B variant.
General Information
| Short Description | Phospho-PDE3B Blocking Peptide is synthetically produced from the 260-310 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | PDE3B |
| Gene ID | 5140 |
| Uniprot ID | PDE3B_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 260-310 on human PDE3B protein. Selective only for PDE3B variant. |
| Immunogen Region | 260-310 |
Additional Info
| Tissue Specificity | Abundant in adipose tissues. |
| Post Translational Modifications | Phosphorylation at Ser-295 mediates insulin-induced activation of PDE3B. |
| Function | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process. Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling. Controls cardiac contractility by reducing cAMP concentration in cardiocytes. |
| Peptide Name | Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3bCgipde1Cgip1Cyclic Gmp-Inhibited Phosphodiesterase BCgi-Pde B |
| Database Links | Reactome: R-HSA-165160Reactome: R-HSA-418555 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Peptide Names | Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3b proteinCgipde1 proteinCgip1 proteinCyclic Gmp-Inhibited Phosphodiesterase B proteinCgi-Pde B proteinPDE3B protein |
Information sourced from Uniprot.org