| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
PDE3A Blocking Peptide for STJ502266 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
PDE3A |
| Gene ID: |
5139 |
| Uniprot ID: |
PDE3A_HUMAN |
| Specificity: |
This blocking peptide is recommended for use in combination with PDE3A antibody, STJ502266 |
| Immunogen: |
CQATGYPLAEVSWPNVSVPA |
| Function | Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has also activity toward cUMP. Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling. |
| Peptide Name | Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3aCyclic Gmp-Inhibited Phosphodiesterase ACgi-Pde ACgmp-Inhibited Camp PhosphodiesteraseCgi-Pde |
| Database Links | Reactome: R-HSA-418555 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCytoplasmCytosol |
| Alternative Peptide Names | Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3a proteinCyclic Gmp-Inhibited Phosphodiesterase A proteinCgi-Pde A proteinCgmp-Inhibited Camp Phosphodiesterase proteinCgi-Pde proteinPDE3A protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
