PDE2A1 Positive Control peptide (STJ505339)
SPECIFICATIONS
General Information
| Short Description | PDE2A1 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications | WB |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | WB: 1:500 |
| Formulation | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | PDE2A |
| Gene ID | 5138 |
| Uniprot ID | PDE2A_HUMAN |
Additional Info
| Tissue Specificity | Widely expressed. Expressed in brain, with high expression observed in the corpus striatum. Also expressed in heart, placenta, lung, skeletal muscle, kidney and pancreas. |
| Function | cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP. Plays a role in cell growth and migration. Isoform PDE2A2: Regulates mitochondrial cAMP levels and respiration. Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L. |
| Peptide Name | Cgmp-Dependent 3' -5'-Cyclic PhosphodiesteraseCyclic Gmp-Stimulated PhosphodiesteraseCgs-PdeCgspde |
| Database Links | Reactome: R-HSA-418457Reactome: R-HSA-418555 |
| Cellular Localisation | Isoform Pde2a3: Cell MembraneLipid-AnchorIsoform Pde2a2: Mitochondrion MatrixMitochondrion Inner MembraneMitochondrion Outer MembraneIsoform Pde2a1: CytoplasmIsoform 5: Mitochondrion |
| Alternative Peptide Names | Cgmp-Dependent 3' -5'-Cyclic Phosphodiesterase proteinCyclic Gmp-Stimulated Phosphodiesterase proteinCgs-Pde proteinCgspde proteinPDE2A protein |
Information sourced from Uniprot.org