PDE12 Blocking Peptide peptide (STJ505294)
SPECIFICATIONS
ImmunogenSynthetic peptide taken within amino acid region 420-470 on human PDE12A protein.
General Information
| Short Description | PDE12 Blocking Peptide is synthetically produced from the 420-470 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Immunogen | Synthetic peptide taken within amino acid region 420-470 on human PDE12A protein. |
| Immunogen Region | 420-470 |
Additional Info
| Background | Enzyme that cleaves 2 NA, 5 NA-phosphodiester bond linking adenosines of the 5 NA-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3 NA, 5 NA-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system. |
Information sourced from Uniprot.org