PDE11A3 Blocking Peptide peptide (STJ504596)
SPECIFICATIONS
ImmunogenSynthetic peptide unique to PDE11A3 variant
General Information
| Short Description | PDE11A3 Blocking Peptide is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20ยฐC for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | PDE11A |
| Gene ID | 50940 |
| Uniprot ID | PDE11_HUMAN |
| Immunogen | Synthetic peptide unique to PDE11A3 variant |
Additional Info
| Tissue Specificity | Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex. |
| Function | Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. |
| Peptide Name | Dual 3' -5'-Cyclic-Amp And -Gmp Phosphodiesterase 11aCamp And Cgmp Phosphodiesterase 11a |
| Database Links | Reactome: R-HSA-418457Reactome: R-HSA-418555 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Peptide Names | Dual 3' -5'-Cyclic-Amp And -Gmp Phosphodiesterase 11a proteinCamp And Cgmp Phosphodiesterase 11a proteinPDE11A protein |
Information sourced from Uniprot.org