PDE11A Blocking Peptide peptide (Phospho) (S117/S124) (STJ504774)
SPECIFICATIONS
ImmunogenSynthetic peptide taken within amino acid region 100-150 on PDE11A protein. Phosphorylated Ser 117 & 124.
General Information
| Short Description | Phospho-PDE11A Blocking Peptide is synthetically produced from the 100-150 sequence about the S117/S124 and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | PDE11A |
| Gene ID | 50940 |
| Uniprot ID | PDE11_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 100-150 on PDE11A protein. Phosphorylated Ser 117 & 124. |
| Immunogen Region | 100-150 |
Additional Info
| Tissue Specificity | Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex. |
| Function | Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. |
| Peptide Name | Dual 3' -5'-Cyclic-Amp And -Gmp Phosphodiesterase 11aCamp And Cgmp Phosphodiesterase 11a |
| Database Links | Reactome: R-HSA-418457Reactome: R-HSA-418555 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Peptide Names | Dual 3' -5'-Cyclic-Amp And -Gmp Phosphodiesterase 11a proteinCamp And Cgmp Phosphodiesterase 11a proteinPDE11A protein |
Information sourced from Uniprot.org