| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
OTOP1 Positive Control for STJ505980 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
OTOP1 |
| Gene ID: |
133060 |
| Uniprot ID: |
OTOP1_HUMAN |
| Specificity: |
This is positive control is recommended for use in combination with OTOP1 antibody STJ505980. |
| Immunogen: |
Puriied Otopetrin-1. |
| Function | Proton-selective channel that specifically transports protons into cells. Proton channel activity is only weakly-sensitive to voltage. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration. Probably acts by maintaining the pH appropriate for formation of otoconia. Regulates purinergic control of intracellular calcium in vestibular supporting cells. May be involved in sour taste perception in sour taste cells by mediating entry of protons within the cytosol. Also involved in energy metabolism, by reducing adipose tissue inflammation and protecting from obesity-induced metabolic dysfunction. |
| Peptide Name | Proton Channel Otop1Otopetrin-1Hotop1 |
| Database Links | Reactome: R-HSA-9729555 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinDetected In The Gelatinous Membrane Overlying The Inner Ear Macular Epithelium |
| Alternative Peptide Names | Proton Channel Otop1 proteinOtopetrin-1 proteinHotop1 proteinOTOP1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
