| Tissue Specificity | Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. |
| Function | Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. |
| Peptide Name | Oligodendrocyte Transcription Factor 2Oligo2Class B Basic Helix-Loop-Helix Protein 1Bhlhb1Class E Basic Helix-Loop-Helix Protein 19Bhlhe19Protein Kinase C-Binding Protein 2Protein Kinase C-Binding Protein Rack17 |
| Cellular Localisation | NucleusCytoplasmThe Nls Contained In The Bhlh Domain Could Be Masked In The Native Form And Translocation To The Nucleus Could Be Mediated By Interaction Either With Class E Bhlh Partner Protein Or With Nkx2-2 |
| Alternative Peptide Names | Oligodendrocyte Transcription Factor 2 proteinOligo2 proteinClass B Basic Helix-Loop-Helix Protein 1 proteinBhlhb1 proteinClass E Basic Helix-Loop-Helix Protein 19 proteinBhlhe19 proteinProtein Kinase C-Binding Protein 2 proteinProtein Kinase C-Binding Protein Rack17 proteinOLIG2 proteinBHLHB1 proteinBHLHE19 proteinPRKCBP2 proteinRACK17 protein |
Information sourced from Uniprot.org
