| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
NM23A Blocking Peptide is synthetically produced from the 1-100 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
NME1 |
| Gene ID: |
4830 |
| Uniprot ID: |
NDKA_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
Synthetic peptide taken within amino acid region 1-100 on human NDKA protein. |
| Tissue Specificity | Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. |
| Function | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. |
| Peptide Name | Nucleoside Diphosphate Kinase ANdk ANdp Kinase AGranzyme A-Activated DnaseGaadMetastasis Inhibition Factor Nm23Nm23-H1Tumor Metastatic Process-Associated Protein |
| Database Links | Reactome: R-HSA-499943Reactome: R-HSA-9748787Reactome: R-HSA-9755088 |
| Cellular Localisation | CytoplasmNucleusCell-Cycle Dependent Nuclear Localization Which Can Be Induced By Interaction With Epstein-Barr Viral Proteins Or By Degradation Of The Set Complex By Gzma |
| Alternative Peptide Names | Nucleoside Diphosphate Kinase A proteinNdk A proteinNdp Kinase A proteinGranzyme A-Activated Dnase proteinGaad proteinMetastasis Inhibition Factor Nm23 proteinNm23-H1 proteinTumor Metastatic Process-Associated Protein proteinNME1 proteinNDPKA proteinNM23 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
