NKG2D Blocking Peptide for STJ501924 is synthetically produced from the 180-230 sequence and is suitable for use in western blot applications.
Applications
Immunodepletion/Immunocompetition
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Formulation
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction
Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Synthetic peptide taken within amino acid region 180-230 on rat NKG2D protein.
Immunogen Region
180-230
Specificity
This blocking peptide is recommended for use in combination with NKG2D antibody, STJ501924
Additional Info
Tissue Specificity
Expressed by natural killer cells and by resting thoracic duct CD4+ and CD8+ T-cells, but not by thymocytes or other hemopoietic cells. Expressed by DC cells.
Function
Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins.
Peptide Name
Nkg2-D Type Ii Integral Membrane ProteinKiller Cell Lectin-Like Receptor Subfamily K Member 1Nk Cell Receptor DNk Lectin-Like ReceptorNkllrNkg2-D-Activating Nk ReceptorNkr-P2Cd Antigen Cd314
Cell MembraneSingle-Pass Type Ii Membrane ProteinColocalized With Hcst On The Cell Surface
Alternative Peptide Names
Nkg2-D Type Ii Integral Membrane Protein proteinKiller Cell Lectin-Like Receptor Subfamily K Member 1 proteinNk Cell Receptor D proteinNk Lectin-Like Receptor proteinNkllr proteinNkg2-D-Activating Nk Receptor proteinNkr-P2 proteinCd Antigen Cd314 proteinKlrk1 proteinNkg2d proteinNkrp2 protein
