Niemann Pick C1 Blocking Peptide peptide (STJ504424)
SPECIFICATIONS
ImmunogenSynthetic peptide taken within amino acid region 1228-1278 on human Niemann-Pick C1 protein.
General Information
| Short Description | Niemann Pick C1 Blocking Peptide is synthetically produced from the 1228-1278 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | WB: IHC: 1:100ICC: 1:100IF: 1:100 |
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20ยฐC for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | NPC1 |
| Gene ID | 4864 |
| Uniprot ID | NPC1_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 1228-1278 on human Niemann-Pick C1 protein. |
| Immunogen Region | 1228-1278 |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). Inhibits cholesterol-mediated mTORC1 activation throught its interaction with SLC38A9. (Microbial infection) Acts as an endosomal entry receptor for ebolavirus. |
| Peptide Name | Npc Intracellular Cholesterol Transporter 1Niemann-Pick C1 Protein |
| Database Links | Reactome: R-HSA-8964038 |
| Cellular Localisation | Late Endosome MembraneMulti-Pass Membrane ProteinLysosome Membrane |
| Alternative Peptide Names | Npc Intracellular Cholesterol Transporter 1 proteinNiemann-Pick C1 Protein proteinNPC1 protein |
Information sourced from Uniprot.org