| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Nicotinic Acetylcholine Receptor alpha 7 Positive Control for STJ501865 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: | WB: 1:250 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | Chrna7 |
| Gene ID: | 25302 |
| Uniprot ID: | ACHA7_RAT |
| Specificity: | This is positive control is recommended for use in combination with Nicotinic Acetylcholine Receptor alpha 7 antibody STJ501865. |
| Post Translational Modifications | Glycosylations at Asn-46, Asn-90 and Asn-133 are essential for TMEM35A/NACHO-mediated proper subunit assembly and trafficking to the cell membrane. |
| Function | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. |
| Peptide Name | Neuronal Acetylcholine Receptor Subunit Alpha-7 |
| Database Links | Reactome: R-RNO-629594 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell MembraneRic3 Promotes Its Trafficking To The Cell MembraneTmem35a/Nacho Promotes Its Trafficking To The Cell Membrane |
| Alternative Peptide Names | Neuronal Acetylcholine Receptor Subunit Alpha-7 proteinChrna7 proteinAcra7 protein |
Information sourced from Uniprot.org
