| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
MyoD1 Blocking Peptide is synthetically produced from the 280-330 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
MYOD1 |
| Gene ID: |
4654 |
| Uniprot ID: |
MYOD1_HUMAN |
| Immunogen Region: |
280-330 |
| Immunogen: |
Synthetic peptide taken within amino acid sequence 280-330 on human MyoD1 protein. |
| Post Translational Modifications | Phosphorylated by CDK9. This phosphorylation promotes its function in muscle differentiation. Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function. Ubiquitinated on the N-terminus.which is required for proteasomal degradation. Methylation at Lys-104 by EHMT2/G9a inhibits myogenic activity. |
| Function | Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins. |
| Peptide Name | Myoblast Determination Protein 1Class C Basic Helix-Loop-Helix Protein 1Bhlhc1Myogenic Factor 3Myf-3 |
| Database Links | Reactome: R-HSA-525793 |
| Cellular Localisation | Nucleus |
| Alternative Peptide Names | Myoblast Determination Protein 1 proteinClass C Basic Helix-Loop-Helix Protein 1 proteinBhlhc1 proteinMyogenic Factor 3 proteinMyf-3 proteinMYOD1 proteinBHLHC1 proteinMYF3 proteinMYOD protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
