| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | MyD88 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: | WB: 1:500-1:750 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | MYD88 |
| Gene ID: | 4615 |
| Uniprot ID: | MYD88_HUMAN |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Ubiquitinated.undergoes 'Lys-63'-linked polyubiquitination. OTUD4 specifically hydrolyzes 'Lys-63'-linked polyubiquitinated MYD88. |
| Function | Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses such as SARS-CoV-2, SARS-CoV and HIV-1, induces IL1B release through NLRP3 inflammasome activation. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine. |
| Peptide Name | Myeloid Differentiation Primary Response Protein Myd88 |
| Database Links | Reactome: R-HSA-1236974Reactome: R-HSA-1257604Reactome: R-HSA-166058Reactome: R-HSA-1810476Reactome: R-HSA-209543Reactome: R-HSA-3134963Reactome: R-HSA-5602498Reactome: R-HSA-5602680Reactome: R-HSA-5603037Reactome: R-HSA-5603041Reactome: R-HSA-6811558Reactome: R-HSA-9020702Reactome: R-HSA-975110Reactome: R-HSA-975138Reactome: R-HSA-975155Reactome: R-HSA-975871 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Peptide Names | Myeloid Differentiation Primary Response Protein Myd88 proteinMYD88 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance