| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | MRP1 Positive Control for STJ501801 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: | WB: 1:500 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | Abcc1 |
| Gene ID: | 24565 |
| Uniprot ID: | MRP1_RAT |
| Specificity: | This is positive control is recommended for use in combination with MRP1 antibody STJ501801. |
| Tissue Specificity | Skeletal muscle, brain, heart, spleen, lung and kidney. |
| Post Translational Modifications | Glycosylated. |
| Function | Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation. Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells. |
| Peptide Name | Multidrug Resistance-Associated Protein 1 Atp-Binding Cassette Sub-Family C Member 1 Glutathione-S-Conjugate-Translocating Atpase Abcc1 Leukotriene C(4 Transporter Ltc4 Transporter |
| Database Links | Reactome: R-RNO-1660661 Reactome: -RNO-189483 Reactome: -RNO-2142691 Reactome: -RNO-382556 Reactome: -RNO-9707564 Reactome: -RNO-9753281 Reactome: -RNO-9758890 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Peptide Names | Multidrug Resistance-Associated Protein 1 protein Atp-Binding Cassette Sub-Family C Member 1 protein Glutathione-S-Conjugate-Translocating Atpase Abcc1 protein Leukotriene C(4 Transporter protein Ltc4 Transporter protein Abcc1 protein Mrp1 protein |
Information sourced from Uniprot.org