This VGF Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse serum, plasma, tissue homogenates or other biological fluids..
Applications
ELISA
Reactivity
Mouse
Sensitivity
16.3pg/mL
Detection Limit
31.2-2000pg/mL
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Storage Instruction
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
serum, plasma, tissue homogenates or other biological fluids.
Additional Info
Tissue Specificity
Post Translational Modifications
Function
Neurosecretory protein VGF: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner. VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain. Neuroendocrine regulatory peptide-1: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons. Neuroendocrine regulatory peptide-1: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons. Also stimulates feeding behavior in an orexin-dependent manner in the hypothalamus. Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying. VGF-derived peptide TLQP-21: Secreted multifunctional peptide that interacts with different receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation as well as lipolysis. Activates the G-protein-coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes. Interacts with gC1qR receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity. VGF-derived peptide TLQP-62: Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation. Also induces insulin secretion in insulinoma cells by increasing intracellular calcium mobilization.
Neurosecretory Protein Vgf: SecretedCytoplasmic VesicleSecretory VesicleStored In Secretory Vesicles And Then SecretedNerp Peptides Colocalize With Vasopressin In The Storage Granules Of Hypothalamus
