Mouse TNFR1 (CD120a) protein (Recombinant) (STJP000489)
SPECIFICATIONS
HostHEK293
ConjugationUnconjugated
ImmunogenOptimized DNA sequence encoding extracellular domain of Mouse TNF receptor type 1 (TNFR1) including a C-terminal 6His tag was expressed in HEK293 cells. NA
General Information
| Short Description | Recombinant-Mouse TNFR1 (CD120a)-protein was developed from hek293. For use in research applications. |
| Host | HEK293 |
| Note | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | 0.2 Mu m filtered PBS solution, pH7.2. |
| Storage Instruction | Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Immunoreactivity | Recombinant Mouse TNF receptor 1 (CD120a) activity was determined by the ability to inhibit the TNF Alpha mediated cytotoxicity in the L929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is |
Target Information
| Gene Symbol | Tnfrsf1a |
| Gene ID | 21937 |
| Uniprot ID | TNR1A_MOUSE |
| Immunogen | Optimized DNA sequence encoding extracellular domain of Mouse TNF receptor type 1 (TNFR1) including a C-terminal 6His tag was expressed in HEK293 cells. NA |
| Immunogen Region | ECD |
Additional Info
| Post Translational Modifications | (Microbial infection) Glycosylated at Arg-376 by S.typhimurium protein Ssek3: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions. |
| Function | Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 1aTumor Necrosis Factor Receptor 1Tnf-R1Tumor Necrosis Factor Receptor Type ITnf-RiTnfr-IP55P60Cd Antigen Cd120a |
| Database Links | Reactome: R-MMU-5357786Reactome: -MMU-5357905Reactome: -MMU-5357956Reactome: -MMU-5626978Reactome: -MMU-5669034Reactome: -MMU-75893 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinGolgi Apparatus Membrane |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 1a proteinTumor Necrosis Factor Receptor 1 proteinTnf-R1 proteinTumor Necrosis Factor Receptor Type I proteinTnf-Ri proteinTnfr-I proteinP55 proteinP60 proteinCd Antigen Cd120a proteinTnfrsf1a proteinTnfr-1 proteinTnfr1 protein |
Information sourced from Uniprot.org