Mouse TNFR1 (CD120a) protein (Recombinant) (STJP000489)

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STJP000489

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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse TNFR1 (CD120a)-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: 0.2 Mu m filtered PBS solution, pH7.2.
Storage Instruction: Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Immunoreactivity: Recombinant Mouse TNF receptor 1 (CD120a) activity was determined by the ability to inhibit the TNF Alpha mediated cytotoxicity in the L929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is
Gene Symbol: Tnfrsf1a
Gene ID: 21937
Uniprot ID: TNR1A_MOUSE
Immunogen Region: ECD
Immunogen: Optimized DNA sequence encoding extracellular domain of Mouse TNF receptor type 1 (TNFR1) including a C-terminal 6His tag was expressed in HEK293 cells. NA
Post Translational Modifications (Microbial infection) Glycosylated at Arg-376 by S.typhimurium protein Ssek3: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions.
Function Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 1a
Tumor Necrosis Factor Receptor 1
Tnf-R1
Tumor Necrosis Factor Receptor Type I
Tnf-Ri
Tnfr-I
P55
P60
Cd Antigen Cd120a
Database Links Reactome: R-MMU-5357786
Reactome: -MMU-5357905
Reactome: -MMU-5357956
Reactome: -MMU-5626978
Reactome: -MMU-5669034
Reactome: -MMU-75893
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Golgi Apparatus Membrane
Alternative Protein Names Tumor Necrosis Factor Receptor Superfamily Member 1a protein
Tumor Necrosis Factor Receptor 1 protein
Tnf-R1 protein
Tumor Necrosis Factor Receptor Type I protein
Tnf-Ri protein
Tnfr-I protein
P55 protein
P60 protein
Cd Antigen Cd120a protein
Tnfrsf1a protein
Tnfr-1 protein
Tnfr1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance