| Post Translational Modifications | Proteolytically processed.by an autocatalytic mechanism. Autocleavage induces active conformation. |
| Function | Plasma membrane-anchored serine protease that cleaves at arginine residues. Participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia. (Microbial infection) Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9) and is involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity. |
| Protein Name | Transmembrane Protease Serine 2EpitheliasinPlasmic Transmembrane Protein X Cleaved Into - Transmembrane Protease Serine 2 Non-Catalytic Chain - Transmembrane Protease Serine 2 Catalytic Chain |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinTransmembrane Protease Serine 2 Catalytic Chain: SecretedActivated By Cleavage And Secreted |
| Alternative Protein Names | Transmembrane Protease Serine 2 proteinEpitheliasin proteinPlasmic Transmembrane Protein X Cleaved Into - Transmembrane Protease Serine 2 Non-Catalytic Chain - Transmembrane Protease Serine 2 Catalytic Chain proteinTmprss2 protein |
Information sourced from Uniprot.org
