Mouse TIMP-1 (Metalloproteinase Inhibitor 1) Antibody Pair (STJAP00267)
SPECIFICATIONS
ClonalityMonoclonal/Polyclonal
HostRat/Goat
ConjugationUnconjugated/Biotin
ImmunogenCapture immunogen: Recombinant Mouse TIMP-1 protein.Detection Immunogen: Recombinant Mouse TIMP-1 protein.
General Information
| Short Description | This TIMP-1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Rat/Goat |
| Reactivity | Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Polyclonal |
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Protein A or G.Detection Purification: Antigen Affinity. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Timp1 |
| Gene ID | 21857 |
| Uniprot ID | TIMP1_MOUSE |
| Immunogen | Capture immunogen: Recombinant Mouse TIMP-1 protein.Detection Immunogen: Recombinant Mouse TIMP-1 protein. |
Additional Info
| Post Translational Modifications | The activity of TIMP1 is dependent on the presence of disulfide bonds. N-glycosylated. |
| Function | Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. |
| Protein Name | Metalloproteinase Inhibitor 1Collagenase Inhibitor 16c8 FibroblastErythroid-Potentiating ActivityEpaTpa-S1Tpa-Induced ProteinTissue Inhibitor Of Metalloproteinases 1Timp-1 |
| Database Links | Reactome: R-MMU-114608Reactome: -MMU-1592389Reactome: -MMU-381426Reactome: -MMU-8957275Reactome: -MMU-9839383 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Metalloproteinase Inhibitor 1 antibody pairCollagenase Inhibitor 16c8 Fibroblast antibody pairErythroid-Potentiating Activity antibody pairEpa antibody pairTpa-S1 antibody pairTpa-Induced Protein antibody pairTissue Inhibitor Of Metalloproteinases 1 antibody pairTimp-1 antibody pairTimp1 antibody pairTimp antibody pairTimp-1 antibody pair |
Information sourced from Uniprot.org