Mouse ST2 (Interleukin-1 Receptor-Like 1) Antibody Pair (STJAP00576)
General Information
| Short Description | This ST2 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Goat/Goat |
| Reactivity | Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Antigen Affinity.Detection Purification: Antigen Affinity. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
| Determination Method | Colormetric |
Target Information
| Gene Symbol | Il1rl1 |
| Gene ID | 17082 |
| Uniprot ID | ILRL1_MOUSE |
| Immunogen | Capture immunogen: Recombinant Mouse ST2 protien.Detection Immunogen: Recombinant Mouse ST2 protien. |
| Sample Type | Serum, plasma and other biological fluids |
Additional Info
| Post Translational Modifications | Phosphorylated by GSK3B at Ser-442.leading to proteasomal degradation. Ubiquitinated at Lys-326 in a FBXL19-mediated manner.leading to proteasomal degradation. Ubiquitination by TRAF6 via 'Lys-27'-linked polyubiquitination and deubiquitination by USP38 serves as a critical regulatory mechanism for fine-tuning IL1RL1-mediated inflammatory response. |
| Function | Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. Isoform B: Inhibits IL-33 signaling. |
| Protein Name | Interleukin-1 Receptor-Like 1Interleukin-33 Receptor Alpha ChainLymphocyte Antigen 84Protein St2Protein T1 |
| Database Links | Reactome: R-MMU-1257604Reactome: -MMU-6811558Reactome: -MMU-9014843 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform B: Secreted |
| Alternative Antibody Pair Names | Interleukin-1 Receptor-Like 1 antibody pairInterleukin-33 Receptor Alpha Chain antibody pairLymphocyte Antigen 84 antibody pairProtein St2 antibody pairProtein T1 antibody pairIl1rl1 antibody pairLy84 antibody pairSt2 antibody pairSte2 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Mouse ST2 (Interleukin-1 Receptor-Like 1) Antibody Pair (STJAP00576)
This antibody pair detects mouse ST2, also known as Interleukin-1 Receptor-Like 1 (UniProt P14719), and has confirmed reactivity in mouse samples. It is not validated for detection of ST2 in other species.
The capture antibody is unconjugated and the detection antibody is biotin-conjugated. Both are goat-derived, purified by antigen affinity, and supplied at 0.5 mg/mL.
This pair is validated for use in ELISA. No other assay formats are listed in the product specifications.
Compatible sample types include serum, plasma, and other biological fluids. This product is for research use only and is not intended for diagnostic or therapeutic applications.
The capture antibody is formulated in PBS with 0.04% Proclin 300 and 50% glycerol at pH 7.5. The detection antibody is formulated in PBS with 0.04% Proclin 300, 1% protective protein, and 50% glycerol at pH 7.5. Both components should be stored at -20°C for long-term storage, and freeze-thaw cycles should be avoided.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.