Tissue Specificity | Expressed in the ovary. Localized to granulosa cells of periovulatory follicles and corpora lutea. Weakly expressed in adult tissues including kidney, brain and lung. |
Post Translational Modifications | |
Function | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. |
Protein Name | Secreted Frizzled-Related Sequence Protein 4Frp-4Sfrp-4 |
Database Links | |
Cellular Localisation | Secreted |
Alternative ELISA Names | Secreted Frizzled-Related Sequence Protein 4 ELISA kitFrp-4 ELISA kitSfrp-4 ELISA kitSfrp4 ELISA kit |
output | |
Information sourced from Uniprot.org